One part of your roaming backup strategy should include offsite/Internet based backup services. The one I use is Jungledisk which has recently updated its software to version 2.5b. Jungledisk makes use of the Amazon S3 storage service as a destination (and soon to be Rackspace after its acquisition by them).
When I upgraded I found that my main NAS storage was not being backed up, showing zero files present and a message saying that the username and password was incorrect/not present. Before the upgrade it all worked well, and after the upgrade nothing was doing for the network share based locations.
The problem was simple and related to a new feature introduced in this version of Jungledisk – the ability to backup without being logged in. Jungledisk runs as a service to provide this feature, and it does so using its own credentials which did not have access to the NAS drive. The solution is to change the logon credentials of the new JungleDiskService to an account that actually has both access to the local machine (for the local file storage backups) and to the network share from which you are also backing up. Changing the credentials of a service in Windows is well documented on the internet, so I will not go into it here.
After the change (and an exit and restart of the client), backups continued in their normal effective way.
A major lesson learned here also is… make sure that you test the software upgrade first when it is software that your business depends on.